BIRB796, the Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances the Efficacy of Chemotherapeutic Agents in ABCB1 Overexpression Cells
Figure 1
Cytotoxicity of BIRB796 in the drug-resistant and parental sensitive cancer cells.
The structure of BIRB796 (A). The protein expression of ABCB1 in KB, KBV200, MCF-7, MCF-7/ADR, HEK293/pcDNA3.1 and HEK293/ABCB1; ABCG2 in S1 and S1-M1-80; ABCC1 in HL60 and HL60/ADR (B). MTT cytotoxicity assay was used to measure cell survival in KB and KBV200 (C), MCF-7 and MCF-7/ADR (D), HEK293/pcDNA3.1 and HEK293/ABCB1 (E), S1 and S1-M1-80 (F), HL60 and HL60/ADR (G) treated with BIRB796 for 72 h. Each point represents the mean ± standard deviations (SDs) for three determinations. Each experiment was performed in four replicate wells.