Sleep-Wake Sensitive Mechanisms of Adenosine Release in the Basal Forebrain of Rodents: An In Vitro Study
Figure 4
2h sleep deprivation causes an increase in basal forebrain adenosine release in rats.
Adenosine release evoked by AMPA in slices from 2 h SD rats was compared to control rats sacrificed at the same point in the diurnal cycle without sleep deprivation. (a) Raw data traces of representative experiments of sleep deprived and control rats adjusted to the adenosine calibration. (b) Slices from 2 h SD rats (n = 13) had greater ADO’ responses than controls (n = 14) with the asterisk indicating significance (Mann-Whitney test, p<0.05). (c) The cumulative probability graph illustrates the distribution of individual ADO’ responses for control (black fill) and 2 h SD (white fill).