Green Tea Polyphenols Reduced Fat Deposits in High Fat-Fed Rats via erk1/2-PPARγ-Adiponectin Pathway
Figure 5
Inhibition of erk1/2 and GTPs treatment attenuated the phosphorylation and down-expression of PPARγ and erk1/2 activation in cultured VAT under high glucose condition.
The cultured VAT explants were treated with GTPs and PD98059, respectively. High glucose incubation down-regulated the PPARγ mRNA (A, N = 6) and protein expression (B, N = 3) while up-regulated the phosphorylation of PPARγ (C, N = 3) and phosphorylation of erk1/2 (D, N = 3), all the above effects could be attenuated by GTPs or PD98059. (*P<0.05 vs. the control; # P<0.05 vs. the HG group). Data is expressed as Mean ± SEM.