Abnormal Ca2+ Spark/STOC Coupling in Cerebral Artery Smooth Muscle Cells of Obese Type 2 Diabetic Mice
Figure 3
SR Ca2+ load in CASMCs of diabetic mouse. A
. Representative caffeine-induced Ca2+ transients in Fura-2 loaded CASMCs from control (upper graph) and db/db mice (bottom graph); bottom traces indicate the start and end of caffeine applications (10 mmol/L). Breaks in x-axis indicate a 5-min interval between the first and the second caffeine application to allow the recovery of SR Ca2+ stores. B. Bar graph of averaged caffeine-induced Ca2+ transients. *P<0.05 C. Bar graph of averaged basal [Ca2+]i concentrations in CASMCs from control (open bar, n = 50 cells) and db/db mice (fill bar, n = 62 cells).