The Anorectic Effect of GLP-1 in Rats Is Nutrient Dependent
Figure 4
The impact of glucokinase on the anorexic effect of GLP-1 in fed animals.
a) Food intake was equally suppressed in WT (squares) and GK+/− (circles) mice after IP injection of EX4 (solid symbols) vs. saline (open symbols; *p<0.05 at 4 h after injection). Food intake was also equally suppressed at 4 h by IP GLP-1+vildagliptin in WT (b) and GK+/− (c) mice (*p<0.05 at 4 h post-injection). For b) and c), open circle, IP saline+IP saline; closed circle, IP saline+IP vildagliptin; open square, IP GLP-1+IP saline; closed square, IP GLP-1+IP vildagliptin.