Tumor Phosphatidylinositol-3-Kinase Signaling and Development of Metastatic Disease in Locally Advanced Rectal Cancer
Figure 4
Tumor ex vivo phosphorylation profiles discriminating tumor KRAS/BRAF mutation status in locally advanced rectal cancer.
The 63 tumor samples are ordered along the horizontal axis, annotated by wild-type or mutated KRAS/BRAF and marked for other gene mutations as specified, while the 11 discriminating kinase substrates (P-value range 0.0034–0.049 on comparison of KRAS/BRAF wild-type tumors as a whole group with the entire group of tumors harboring such mutations) are depicted along the vertical axis. For each peptide substrate, position(s) of the tyrosine phosphorylation site(s) within the protein is indicated. Red corresponds to higher and blue to lower substrate phosphorylation levels.