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Elevated Homocysteine by Levodopa Is Detrimental to Neurogenesis in Parkinsonian Model

Figure 1

Phenotype and proliferative capacity of cultured NPCs.

NPCs isolated from the SVZ exhibited no GFAP-positive or OX-42-positive cells (A and B). Most NPCs were immunostained with nestin (C and E), Ki67 (F and G), and MAP 2 (I and K). These marker-positive NPCs were visualized using fluorescent secondary antibodies conjugated to DAPI (D, G, and J). Scale bar: 10 µm.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0050496.g001