Regulation of CD4+ and CD8+ Effector Responses by Sprouty-1
Figure 8
Spry1 null mice have enhanced clearance of EL-4 tumor cells.
Wild type and Spry1 null mice were subcutaneously injected with EL-4 tumor cells. Mice were monitored for (A) tumor free survival and (B) tumor volume. All experiments were performed at least three times. (C) Wt and Spry1 null T cell mice were injected IV with 250,000 B16 melanoma cells, 14 days later mice were sacrificed and lung tumors were counted. P values indicate statistical significance by student t-test. All experiments were performed at least three times. Data are representative of 10 mice per group.