Efficacy and Mechanism of Angiotensin II Receptor Blocker Treatment in Experimental Abdominal Aortic Aneurysms
Figure 2
Influence of drug treatment on aortic histology.
After sacrifice, aortae were fixed, sectioned and underwent elastin staining and immunostaining for SMCs (SMC α-actin), macrophages (MAC2) and blood vessels (CD31). A–K: Residual medial elastin (A–E) and mural SMCs (F–K) in telmisartan (B, H), irbesartan (C, I), fluvastatin (D, J), doxycycline-treated (E, K) or control mice (A, F). L–V: macrophages (L–P) and endothelial cells (neovessels) (R–V) in telmisartan- (M, S), irbesartan- (N, T), fluvastatin- (O, U) or doxycycline- (P, V) treated mice or untreated control mice (L, R). Representative images, 4–5 mice in each group. Magnification: x200 in A–E, x100 in F–V.