Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
Figure 4
Effect of PA on recruitment of pol β and PAR synthesis.
A. Images one minute after irradiation in wild-type cells, and wild-type cells treated with 300 µM PA. B. Pol β recruitment one minute after irradiation in the absence and presence of PA. C. PAR synthesis at the site of damage one minute after irradiation in the absence and presence of PA. Images are representative; at least five cells were measured for every time point and error bars reflect SEM.