Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
Figure 3
PARP-1 hyperactivation in pol β null cells in response to UV damage.
A. Recruitment of BER proteins as indicated to the site of DNA damage in wild-type and pol β null cells one minute after irradiation. B. Time course of XRCC1 recruitment to the site of damage with the repair times specified. C. PAR synthesis at the site of damage with the repair times specified. Images are representative; at least five cells were measured for every time point and error bars reflect SEM.