Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum
Figure 4
Cholinergic interneurons have the highest level of expression of GRKs and arrestins.
Scatterplots of the optical density of GRK and arrestin immunostaining in medium spiny striatal neurons and interneurons for GRK2 (A), GRK5 (B) arrestin-2 (C), and arrestin-3 (D). Horizontal lines correspond to the median values. The quantification of the GRK or arrestin labeling density was performed on sections triple-stained for GRKs/arrestins, choline acetyltransferase (ChAT) (to label cholinergic interneurons), and parvalbumin (PV) (to label parvalbumin-positive interneurons). The data were analyzed by one-way ANOVA followed by Bonferroni-Dunn post hoc comparison. Large asterisk - p<0.001, small asterisk - p<0.01 to the PV group; pound sign (#) - p<0.001, dollar sign ($) - p<0.01 to the ChAT group according to the post hoc comparison.