Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice
Figure 2
Reduced lymphoproliferation of MRL/lpr mice following repeated transfers of DCs.
(A) Spleen and ILNs from the recipient mice are shown. Photos are representative of the recipient mice (16 weeks of age) at 12 weeks after the transfer. Values are shown as means ± SD (n = 5, 7 and 7 per group respectively). (B) The total cell number in the spleen, and ILNs is shown. Scale bar: 5 mm. (C) T cell numbers in the spleen and ILNs of the recipient mice. Flow cytometry was performed using spleen and ILN cells. The number of CD4+ and CD8+ T cells is shown. (D) B cell (B220+ Thy1.2−) number in the spleen and ILNs of the recipient mice. (E) CD4− CD8− CD3+ DNT cell number in the spleen and ILNs of the recipient mice. Values are shown as means ± SD (n = 5, 7, and 7 respectively per group). *p<0.05, **p<0.005.