Protection of Rabbits and Immunodeficient Mice against Lethal Poxvirus Infections by Human Monoclonal Antibodies
Figure 1
Pre-exposure hmAb protection of SCID mice.
Severe combined immunodeficiency (SCID) mice were treated with a single dose of human anti-H3 hV26, anti-B5 h101, a combination of the two, 2.0 mg of vaccinia immune globulin (VIG), or negative control anti-DNP mAb at day -1 and then infected intravenously via tail vein with 5×104 PFU of vaccinia virus, ACAM2000 lab stock strain; n = 12/group, except for the naïve control [n = 2]. (A) Weights. (B) Survival. (C) Clinical scores. (D) 5% weight loss.