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Genomic Comparison of Escherichia coli O104:H4 Isolates from 2009 and 2011 Reveals Plasmid, and Prophage Heterogeneity, Including Shiga Toxin Encoding Phage stx2

Figure 5

Analysis of prophage content of O104:H4 strains.

A) Location of prophages in the genomes of the EAggEc strains analyzed in this study. Linear maps of the genomes and the location of prophages as boxes are shown. All genome sequences have the same starting position as described in methods. The prophage locations are drawn to scale. Phages are color-coded according to similarity; for example the red box indicates the stx2a phages. The exact genomic locations of the prophages in their respective genomes are given in Table 6. B) Architecture of individual prophages. Phage proteins are colored according to their predicted functions. The stx2ab genes are boxed in red; the island of pyrimidine biosynthesis genes identified as a part of this prophage by Phage_Finder is indicated by the blue box. In all cases the int genes are positioned on the left, regardless of the orientation of the prophage within the chromosome.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0048228.g005