Alveolar Macrophages Play a Key Role in Cockroach-Induced Allergic Inflammation via TNF-α Pathway
Figure 6
Alveolar macrophages are the major source of TNF-α in the GCE-induced asthma model.
(a) Scheme for the alveolar macrophage depletion of GCE-induced asthma model. Cl2MDP, Cl2MDP-containing liposomes; Liposome, control liposomes. (b) Macrophages from BAL fluid and (c) AHR in alveolar macrophage-depleted animals. (d) Intracellular TNF-α production in lung tissue. (e) Relative MFI ratio in “d” panel. * indicates statistical significance between “Liposome/sham” and “Liposome/GCE” (n = 5, p<0.05). # indicates statistical significance between “Liposome/GCE” and “Cl2MDP/GCE” (n = 5, p<0.05). All data are representative of three independent experiments. Liposome/sham, control liposome-treated group; Liposome/GCE, control liposome-treated GCE-treated group; Cl2MDP/sham, Cl2MDP-containing liposome-treated sham group; Cl2MDP/GCE, Cl2MDP-containing liposome-treated GCE-treated group.