Detoxifying Antitumoral Drugs via Nanoconjugation: The Case of Gold Nanoparticles and Cisplatin
Figure 1
Different platinum anticancer drugs approved by the FDA.
The active part of each drug is drawn in black; in all cases it is characterized by the presence of good leaving groups that will allow the Pt atom to bind the target. In red, the amines play a role in the modulation of the activity and distribution of the drug. In the case of cisplatin, the equilibrium that spontaneously occurs inside the cell (where the chloride concentration drops from 100 mM to 4 mM) is also shown.