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Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

Figure 4

βL delays functional decline.

(A)Total distance (B) Measurement of freezing time for cued conditioning (C)Time to fall from an accelerating rotarod (D)Peak tension measurements of grip strength (E)Number of successful trials in pole tests (n = 10–15 for each group) for control (C), calorie restriction (CR), and β-lapachone supplemented (βL) mice. Data represent the mean ± SEM. *P<0.05 versus control; **P<0.001 versus pre-CS.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0047122.g004