5-Fluorouracil Nanoparticles Inhibit Hepatocellular Carcinoma via Activation of the p53 Pathway in the Orthotopic Transplant Mouse Model
Figure 2
Particle size and scanning electron microscope (SEM) image of GC/5-FU.
(A) Particle size graph showing the diameter of GC/5-FU (35.19±9.50 nm). (B) SEM image of GC/5-FU. The particles show spherical structure with a smooth surface and no adhesion between nanoparticles. (C) The in vitro release curve of nanoparticles in simulated body fluid (37°C, pH 7.4). A rapid release was observed from 0 h to 12 h, with a cumulative release percentage of 32.4%. Smooth slow-release occurred between Day 1 and 8, with a cumulative release percentage of 93.50%. During Day 8 to 10, the release reached a plateau, with a cumulative release percentage of 95.70% at Day 10.