Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats
Figure 3
HPLC profile of bilirubin species excreted in bile.
(A) The bile of untreated Gunn rats contained some unconjugated bilirubin, but no bilirubin glucuronides. (B) Bile of the wildtype Wistar-RHA donors contained predominantly bilirubin diglucuronide and monoglucuronide and a very small amount of unconjugated bilirubin. (C) Three months after hepatocyte transplantation following HIR to 1/3 of liver, the pigment profile of bile in transplant-recipient Gunn rats became similar to that of the normal Wistar rats, except that there was still a significant amount of unconjugated bilirubin in the bile. (D) Three months after hepatocyte transplantation following HIR to 2/3 of liver, the pigment profile of bile in transplant-recipient Gunn rats became similar to that of Gunn rats received HIR to 1/3 of liver.