Respiratory Syncytial Virus Reverses Airway Hyperresponsiveness to Methacholine in Ovalbumin-Sensitized Mice
Figure 1
Schematic timeline of the OVA sensitization/challenge and RSV infection protocol.
Mice were sensitized by intraperitoneal (i.p.) injection of OVA in alum at days −28 and −14. From −7 to −3 days, mice were challenged daily by intranasal (i.n.) OVA instillation. Animals were infected with RSV 3 days after the last OVA challenge (day 0). Airway responsiveness to methacholine (MCH) was measured at 2–8 days post-infection (d.p.i.).