The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment
Figure 3
Confirmation of downregulated neocortical GABA pathway mRNAs in HIVE.
GAD1 codes for the rate limiting enzyme in GABA synthesis in presynaptic neurons (glutamic acid decarboxylase, 67 kDa). GABRA1 codes for GABA receptor subunit A1 in postsynaptic neurons. Both of these mRNAs pertain to inhibitory neocortical neurons and were significantly decreased in frontal neocortex in subjects with NCI and HIV encephalitis (Group D). NCI subjects without HIVE did not have altered GABA transcripts (Group C). mRNA is expressed relative to GAPDH mRNA. Mean ± SD, Student’s t test.