Conditional Mesenchymal Disruption of Pkd1 Results in Osteopenia and Polycystic Kidney Disease
Figure 2
Col1a1(3.6)-Cre-mediated deletion of Pkd1 results in osteopenia in Col1a1(3.6)-Cre;Pkd1flox/null newborn mice.
The whole skeleton mineralization (A and B), full-length mineralized femurs (C and D), bone volume of metaphyseal region (E and F), and cortical thickness of cortical bone (G and H) of femurs from Col1a1(3.6)-Cre;Pkd1flox/flox and Col1a(3.6)-Cre; Pkd1flox/null newborn mice by μCT analysis. A Pkd1 gene dose effect was observed during skeletogenesis between Col1a1(3.6)-Cre;Pkd1flox/flox and Col1a(3.6)-Cre; Pkd1flox/null newborn mice. Data represent the mean ± SD from three to four individual samples. *Significant difference from control mice (Pkd1flox/flox or Pkd1flox/+) at P<0.05.