The Importance of Group-Wise Registration in Tract Based Spatial Statistics Study of Neurodegeneration: A Simulation Study in Alzheimer's Disease
Figure 4
Modelling typical atrophy in AD using Demons registration algorithm.
A control image, CON, an AD subject as the target and the deformed control image, , after applying the registration. Ventricular expansion in AD is well modelled in the control subject using the Demons algorithm.