The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer’s Disease Mice
Figure 4
Intravenous and intracerebral injection of hASC reduced Aβ and APP-CT levels and increased neprilysin in Tg2576 mouse brains.
(a) Western blot analysis was performed with lysates from the cortical region of the brains in each group using 6E10 and GAPDH antibodies 4 months after injection. (b, c) Aβ and CT expressions were normalized with those of APP and GAPDH for quantification (n = 5). (d) Neprilysin level was significantly increased in Tg-hASC group (n = 4). All data are represented as mean ± SEM. Asterisk *, P<0.05 by one-way ANOVA.