Myogenic Potential of Whole Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo for Usage in Urinary Incontinence
Figure 5
Bisbenzimide-stained BM-hMSCs (in blue) transplanted into rat bulbocavernosus muscle.
(A) 24 hours after transplantation BM-hMSCs appear undifferentiated with a typical round shape (inset in A, scale bar = 500 µm); (B) one month after engraftment many BM-hMSCs with elongated shape are recognizable among muscular fibers (inset in B, scale bar = 100 µm). (C) At 4 months, migration toward muscle fibers is confirmed by elongated appearance of cells occupying peripheral position (inset b), whereas undifferentiated cells are observed in the core of graft (inset a). Scale bar = 500 µm.