Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2
Figure 1
Effect of dh404 on survival rate and cardiac hypertrophy of mice after TAC.
(A) Effect of dh404 (10 mg/kg/d) on TAC-induced death in C57BL/6J mice. (B) Representative pictures of hearts from sham and TAC operated mice treated with vehicle or dh404 (10 mg/kg/d). (C) Left panel - representative photomicrographs of left ventricular cross-sections depicting myocyte membranes stained with Texas Red-X conjugated wheat germ agglutinin (WGA). Right panel - quantitative left ventricular cardiac myocyte cross-sectional area (MCSA) from 2000 to 5000 myocytes per heart. The number of hearts (n) analyzed is indicated.