Evaluation of Tyrosine Kinase Inhibitor Combinations for Glioblastoma Therapy
Figure 4
Kinase inhibition after treatment with RTK inhibitors.
A. Combining receptor tyrosine kinase inhibitors suppress downstream effectors of growth factor signaling. p-STAT3 was blocked only by the combination treatment, whereas p-AKT was blocked by all the drugs either as single agents or in combinations. The combinations of gefitinib and sunitinib as well as sunitinib and sorafenib were able to inhibit p-AKT, p-MAPK and p-STAT3 in both the GBM oncosphere lines.