Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection
Figure 8
Evaluation of hypoxia, HIF-1α in renal tissue and apoptosis during malaria-associated AKI.
(A) Representative immunohistochemistry, and (B) quantification of renal hypoxia in control and P. berghei ANKA infected mice. (C) mRNA expression of HIF-1α in renal tissue. (D) Evaluation of apoptosis in kidney section of control and P. berghei ANKA infected mice. Each graph represents the mean of 5–10 animals per group ± standard deviation. One-way ANOVA with Bonferroni post-test was performed using GraphPad Prism. * P<0.05 vs control group – day 0, ** p<0.01 vs control group – day 0.