Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection
Figure 4
P. berghei ANKA malaria infection induces endothelium injury and changes in renal architecture.
(A) Renal microvascular permeability change assessed by Evans blue dye and (B) representative pathophysiology of renal tissue stained with hematoxylin-eosin (HE) and examined in light microscopy (Leica DM LB2, Leica Microsystems). Each graph represents the mean of 5–10 animals per group ± standard deviation. One-way ANOVA with Bonferroni post-test was performed using GraphPad Prism. * P<0.05 vs. the control group – day 0, ** p<0.01 vs. the control group – day 0, *** p<0.001 vs. the control group – day 0.