Oxidative Stress and Modification of Renal Vascular Permeability Are Associated with Acute Kidney Injury during P. berghei ANKA Infection
Figure 1
Impairment of renal function during P. berghei ANKA malaria infection.
(A) Parasitemia, and (B) survival of BALB/c mice infected with 106 parasitized erythrocytes by P. berghei ANKA. Renal function was assessed by (C) plasma creatinine, (D) blood urea nitrogen (BUN) and (E) quantification of erythrocyte protoporphyrin estimated on different days after infection. Results represent the mean of 5–10 animals per group ± standard deviation. One-way ANOVA with Bonferroni post-test was performed to renal assessment using GraphPad Prism. * P<0.05 vs the control group – day 0, ** p<0.01 vs the control group – 0 days.