Involvement of Microglia Activation in the Lead Induced Long-Term Potentiation Impairment
Figure 1
Abolishment of hippocampus synaptic potentiation in 100 ppm Pb treated rats.
(A) LTP was induced in hippocampal pyramidal neurons in control rats (n = 13 slices/6 rats, t-test; P<0.001 compared with baseline). (B) LTP was lost in hippocampal pyramidal neurons in Pb treated rats (n = 8 slices/6 rats, t-test; P>0.05 compared with baseline). Pairing training is indicated by an arrow. The dashed line indicates the mean basal synaptic responses.