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Dynamical Behaviors of Rb-E2F Pathway Including Negative Feedback Loops Involving miR449

Figure 8

Bifurcation diagrams of [E2F] with as a control parameter.

Set the AUTO axes to run from 0 to 3 along the x-axis and from −0.01 to 1.2 along the y-axis. (a) with initial values as , [E2F] = 1.1489, [MiR449] = 0, [Myc] = 1.0084, [Cdk6] = 0.2292, [CycE] = 0.2064, [Rb] = 0.0175, [PRb] = 2.5921, [RE] = 0.7793; (b) with initial conditions as , [E2F] = 1.1998, [MiR449] = 0, [Myc] = 1.2245, [Cdk6] = 0.2750, [CycE] = 0.2074, [Rb] = 0.0167, [PRb] = 2.6588, [RE] = 0.6489; (c) with initial values as , [E2F] = 1.2137, [MiR449] = 0, [Myc] = 1.2987, [Cdk6] = 0.2907, [CycE] = 0.2077, [Rb] = 0.0165, [PRb] = 2.6767, [RE] = 0.6136.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0043908.g008