Dynamical Behaviors of Rb-E2F Pathway Including Negative Feedback Loops Involving miR449
Figure 2
Bifurcation diagram of [E2F] with as a control parameter at
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Set the AUTO axes to run from 0 to 1.2 along the x-axis and from −0.05 to 1.25 along the y-axis. The initial values for the simulation are , [E2F] = 0, [MiR449] = 0.004, [Myc] = 0.0280, [Cdk6] = 0.0090, [CycE] = 0, [Rb] = 2.9918, [PRb] = 0.0004, [RE] = 0.0157.