The Retrograde Frequency Response of Passive Dendritic Trees Constrains the Nonlinear Firing Behaviour of a Reduced Neuron Model
Figure 4
Bistable firing behaviour of the DC/AC-RM.
(A). Time course of membrane potentials (middle panel: VS gray, VD black) during the triangular current stimulation to the soma (bottom) and their instantaneous frequencies (top). Three characteristic indexes for detecting the bistable firing of the model: Time To onset of Plateau potential (TTP), Time to End of somatic Spiking (TES) and Difference in Spiking Frequency (DSF). (B). The hysteretic relationship of the frequency responses to current stimuli for the case of (A). (C). Switching behaviour of membrane potentials (VS gray, VD black) under the briefly depolarizing and hyperpolarizing current stimulation protocol (bottom). V, I, F and T are dimensionless voltage, current, firing rate and time respectively.