An Intracameral Injection of Antigen Induces In Situ Chemokines and Cytokines Required for the Generation of Circulating Immunoregulatory Monocytes
Figure 6
Intracameral injection of PI3 Kinase inhibitors along with the antigen prevent the development of ACAID.
Mice received an intracameral injection of OVA or OVA +wortmannin. One week later the mice were immunized with OVA/CFA and one week later footpads were challenged with OVA. Footpad swelling was measured 24 hr after challenge and were compared between immunized mice, naïve mice and those that received an intracameral injection of vehicle + OVA with that of wortmannin and OVA. The experiments were repeated 3X.