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Intranasal Immunization with Nontypeable Haemophilus influenzae Outer Membrane Vesicles Induces Cross-Protective Immunity in Mice

Figure 14

Half maximum total Ig titers in sera from mice intranasally immunized with V. cholerae OMVs.

Depicted are the median half-maximum total Ig titers to OMVs derived from V. cholerae in sera collected at day 39 from mice intranasally immunized with V. cholerae OMVs as well as from nonvaccinated control mice (co) (n = 6 for each group). The error bars indicate the interquartile range of each data set. Significant differences between the data sets are marked by asterisks (P<0.05; Mann-Whitney U test).

Figure 14

doi: https://doi.org/10.1371/journal.pone.0042664.g014