Antitumor Activity of Emodin against Pancreatic Cancer Depends on Its Dual Role: Promotion of Apoptosis and Suppression of Angiogenesis
Figure 8
Effect of emodin on the expression of NF-κB and NF-κB-regulated angiogenesis-related proteins (VEGF, MMP-2, MMP-9, and eNOS).
(A) Immunohistochemistry analysis of the expression of Ki-67, NF-κB, VEGF, MMP-2, MMP-9, and eNOS in orthotopic pancreatic cancer tissues. (B) Western blot analysis of the expression of NF-κB, VEGF, MMP-2, MMP-9, eNOS, VEGFR, and p-eNOS in orthotopic pancreatic cancer tissues. (C) Quantified data of immunohistochemistry analysis are presented. (D) Quantification of the Western blot results was performed by calculating the ratio of the value to the control group. *, P<0.05; #,P>0.05.