HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice
Figure 2
Loss of HSPB2 expression does not alter the cardiac hypertrophic response to transaortic constriction (TAC).
Heart weight (HW) and body weight (BW) were measured at four weeks after TAC in HSPB2wt (grey bars) and HSPB2cKO (black bars) (A) and at eight weeks after TAC in CreTG (white bars), HSPB2wt (grey bars) and HSPB2cKO (black bars) (B). TAC induced significant cardiac hypertrophy in all experimental animals in comparison to sham-operated ones.*P<0.05 compared with each sham group. No difference was observed between the HSPB2 cardiac deficient animals and those expressing HSPB2. The number of animals analyzed in each group is indicated above the bars.