Plasma microRNAs, miR-223, miR-21 and miR-218, as Novel Potential Biomarkers for Gastric Cancer Detection
Figure 2
The expression profile signatures of four miRNAs in the initial analysis.
Scatter dot plots of the plasma levels of four miRNAs in gastric cancer patients (GC, n = 10) and healthy control subjects (NC, n = 10). Scatter dot plots show the plasma levels of miR-223 (A), miR-21 (B), miR-218 (C) and miR-25 (D). The lines in the scatter dot plots denote the medians. (E) Bars of the expression levels of miR-223, miR-21 and miR-218 in primary GC tissues and paired normal tissues. The expression levels of miR-223 were higher in primary GC tissues in seven of the eight patients analyzed (87.5%) and miR-21 in eight patients (100%), whereas miR-218 was lower in seven patients (87.5%) than in paired normal tissues. All assays were repeated three times in duplicates.