Platelets Induce Apoptosis during Sepsis in a Contact-Dependent Manner That Is Inhibited by GPIIb/IIIa Blockade
Figure 5
Sepsis survival and severity in vehicle and eptifibatide treated mice in a cecal slurry sepsis model.
A. Eptifibatide treated mice had lower sepsis scores than vehicle treated mice at time points following drug administration. For example, at the 20 hour injection, the mean±SEM vehicle treated score was 8.4±0.3 while the eptifibatide treated score was 7.4±0.3 (p = 0.01) B. Kaplan-Meier survival curve for vehicle and eptifibatide treated mice in hours after cecal slurry injection. Eptifibatide treated mice survived longer following cecal slurry injection than vehicle treated mice (p = 0.019 by Cox Proportional Hazard Regression).