Constitutive Phosphorylation of Interferon Receptor A-Associated Signaling Proteins in Systemic Lupus Erythematosus
Figure 6
Constitutive association of SOCS1 with IFNAR1 in PBMC.
A. Kinetics of SOCS1 (above) and Jak1 (below) association with the individual chains of the IFNAR before (time 0) and after the addition of recombinant IFNβ for the indicated lengths of time (see text). B. One representative Western blot of the indicated proteins obtained from PBMC cell lysates from one healthy control (C) or one SLE patient (P) co-immunoprecipitated with antisera against IFNAR1 and IFNAR2 before (time 0).