The Acute Phase Reactant Orosomucoid-1 Is a Bimodal Regulator of Angiogenesis with Time- and Context-Dependent Inhibitory and Stimulatory Properties
Figure 7
Effect of ORM1 on angiogenesis in the in vivo aortic ring and CAM assays.
(A). Frozen sections of subcutaneously implanted aortic rings stained by immunoperoxidase for CD31 show fewer microvessels in ORM1-primed implants compared to control. (B). Quantitative analysis shows 32% reduction in angiogenesis in ORM1-primed implants (N = 12; ** = p<0.01). (C). Representative image of ORM1-treated CAM shows increased angiogenesis compared to control. (D). Quantitative analysis demonstrates 30% increase in blood vessels in CAMs treated with 50–300 ng ORM1 (N = 15; *** = p<0.001).