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Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients

Figure 6

Immunohistochemical (IHC) staining of SOX2 in CRC tissues.

(A–D) IHC images of SOX2-positve colorectal cancer tissues. Arrows indicate patches of strong SOX2 staining could indicate active tumor invasion fronts of the tumor capsules. (E–F) IHC images of SOX2-negative colorectal cancer tissues. All images are in 100×. (G) Statistical analysis of the relationship of SOX2 IHC staining with tumor stages, lymph node or liver metastases.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0041335.g006