Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate
Figure 1
AST-120 reduces cardiac fibrosis in the STNx model.
Representative LV images (Picrosirius red staining, magnification, X0.8) show patchy fibrosis, stained in red, in STNx + vehicle which is significantly increased compared to sham. Treatment with AST-120 significantly reduces cardiac fibrosis in the STNx model. *p<0.05, ***p<0.001 vs Sham; ##p<0.01 vs STNx + vehicle.