ATRA Inhibits the Proliferation of DU145 Prostate Cancer Cells through Reducing the Methylation Level of HOXB13 Gene
Figure 3
Polycomb group (PcG) proteins EZH2 and BMI1 participated in HOXB13 transcriptional repression.
The mRNA (A) and protein (B) levels of BMI1, EZH2 and HOXB13 in different malignancy prostate cancer cells, LNCap and DU145. (C) The mRNA levels of HOXB13 and EZH2 in DU145 cells transfected with EZH2 siRNA plasmid. (D) The mRNA levels of HOXB13 and BMI1 in DU145 cells transfected with BMI1 siRNA plasmid. (E) The protein levels of HOXB13 and EZH2 in DU145 cells transfected with EZH2 siRNA plasmid. (F) The protein levels of HOXB13 and BMI1 in DU145 cells transfected with BMI1 siRNA plasmid.