Signal 3 Cytokines as Modulators of Primary Immune Responses during Infections: The Interplay of Type I IFN and IL-12 in CD8 T Cell Responses
Figure 1
Expansion of CD8 T cells shows a complex pattern of dependency on signal 3 cytokines.
105 (Fig. 1 A–D) Thy1.1+ P14.WT, P14.IL-12RKO, P14.IFNARKO or P14.DOKO T cells were transferred into B6 mice (Thy1.2+) followed by infection with rVSVGP, rVVGP, LCMV or rListeriaGP33. Kinetics of P14.WT (•) and P14.IFNARKO, P14.IL12RKO as well as P14. DOKO (○) T cells gated on CD8+ T cells in the blood at indicated time points. Values are expressed as mean ± SEM (n = 3). Results are representative of three independent experiments. IL-12 and type I IFN levels in sera of infected mice as determined by ELISA (for IL-12) or VSV protection assay (for type I IFN) are indicated (Fig. 1 E).