Effect of Short-Term Thyroxine Administration on Energy Metabolism and Mitochondrial Efficiency in Humans
Figure 1
State 3 and state 4 respiration and FCCP-induced maximal respiration of mitochondria isolated from the vastus lateralis before and after 3 days of T4 treatment (n = 8).
State 3, or ADP-stimulated respiration was decreased (p = 0.057) with no change in state 4 (leak-dependent) respiration (p = 0.37). Maximal respiration induced by the addition of the uncoupler FCCP also tended to decrease with T4 treatment (p = 0.07).