Memantine Inhibits α3β2-nAChRs-Mediated Nitrergic Neurogenic Vasodilation in Porcine Basilar Arteries
Figure 4
Effects of memantine on nicotine-induced calcium influx in cultured rat superior cervical ganglion (SCG) neurons.
The neurons were loaded with fluo-4, AM (1 µM) in physiologic buffer and incubated at room temperature for 30 mins. Panel A showing the basal calcium image in each cell. In panel B, nicotine (100 µM) was applied to the medium to induce significant calcium influx into the neurons. Panel C showing that memantine (100 µM) significantly inhibited nicotine-induced calcium influx. In panel D, a complete recovery from the blockade of nicotine-induced calcium influx by memantine was observed 15 mins after washing off memantine. Values are means ± SEM; n indicates number of experiments. *P<0.05 indicates significantly different from control.