Unprocessed Viral DNA Could Be the Primary Target of the HIV-1 Integrase Inhibitor Raltegravir
Figure 3
Circular dichroism analysis of oligonucleotides-drug complexes.
Spectra of LTR34 (A) and LTR32 (B) at 10 µM (black) and difference spectra [LTR32/34 (10 µM)+RAL (10 µM, red; 20 µM, green; 40 µM, blue; 60 µM, orange; and 80 µM, purple)−LTR32/34 (10 µM)], in phosphate buffer pH 6, I = 0.05, and MgCl2 5 mM final concentration.